Summary:
Since Eric Davidson’s work on the organization of regulatory elements in enhancers, syntactic properties of the arrangements – order, distances, orientation – of regulatory sites have been evaluated. There are thus various “enhancer grammars”. In that context I show the difference with the grammatical model of microbial transcriptional regulation. On the other hand, the technological power of artificial intelligence (AI) with the so-called LLMs (large language models) invites us to search for linguistic properties of DNA. I end with questions provoked by this vertex of AI, natural language and genetics.
Julio Collado-Vides, Programa de Genómica Computacional, Centro de Ciencias Genómicas, UNAM, MX