Resumen In plants as in animals, the zygote is formed by the union of the egg and sperm. In animals, there is broad agreement that maternal transcripts and proteins inherited from the egg regulate early embryo development until the zygotic genome becomes transcriptionally active, a process termed the maternal to zygotic transition. In animals, this […]

Resumen Plants sense the hormone abscisic acid (ABA) using chemical-induced dimerization (CID) modules, including the receptor PYR1 and HAB1, a protein phosphatase inhibited by ligand-activated PYR1. This system is unique because of the relative ease with which ligand recognition can be reprogrammed. To expand the PYR1 system, we designed an orthogonal response module that harbors […]

Resumen Biomedical technology innovation holds great promise for the application of stem cells in regenerative medicine. To this end, revolutionary cellular reprogramming techniques have been developed, enabling the production of induced pluripotent stem (iPS) cells and future replacement tissues for any individual. Several groups, including our lab in Leiden, have recently adapted iPS technology to […]