Resumen Stress-inducible biomolecular condensates such as ribonucleoprotein (RNP) granules and DNA damage sites play major roles in cellular organization and physiology. In this talk, I will discuss how the concept of biomolecular condensates has expanded our view of stress responses and has revealed important links to aging-related diseases. I will introduce quantitative bottom-up biochemistry approaches […]

Resumen Heritable traits have traditionally been attributed to mutations in germline DNA. However, emerging research reveals the pivotal role of epigenetic mechanisms, including DNA methylation, histone modifications, and small RNAs in transmitting non-genetic information across generations. In our laboratory, we explore the role of small RNAs in epigenetic inheritance using the model organism Caenorhabditis elegans. […]

Resumen Mi laboratorio se enfoca en el examen exhaustivo de la respuesta inmune contra infecciones virales, adoptando un enfoque holístico. Realizamos investigaciones tanto en células inmunes innatas como adaptativas, y más recientemente ampliamos nuestras investigaciones para comprender la intrincada interacción entre el sistema inmune y sistemas no inmunitarios. Nuestro enfoque de investigación no solo contribuye […]