Resumen de la plática Precision medicine has demonstrated the utility of using -omics technology to improve patient care, most dramatically in the field of oncology. So how do we extend this to the prevention of disease? In this talk, we will discuss how the use of AI, real-time environmental monitoring, and exposomics approaches can extend […]

Resumen de la plática In our bodies we have at least as many bacterial cells as human ones. The human microbiome plays a key role in maintaining our health, and alterations in its composition are linked to multiple health conditions, including those linked to our mental health. In the first part of this talk, I […]

Jean C. Zenklusen. Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, US https://gdc.cancer.gov/about-gdc/gdc-team/jean-claude-zenklusen-phd Frontiers in Genomics

Summary: Since Eric Davidson's work on the organization of regulatory elements in enhancers, syntactic properties of the arrangements - order, distances, orientation - of regulatory sites have been evaluated. There are thus various “enhancer grammars”. In that context I show the difference with the grammatical model of microbial transcriptional regulation. On the other hand, the […]

Resumen de la plática At a big picture level, my group at CMU is focused on studying the adaptive properties of spatial structure, across different biological systems. Spatially-resolved datasets are revolutionizing knowledge across many areas in biology, yet are under-utilized for questions in evolutionary biology. When it comes to understanding the role that population structure […]

Summary: Human microbiomes are remarkably person specific. In the skin microbiome, individuals have similar species, yet each person has a unique consortia of strains. How these unique consortia form and persist remains a fundamental open question. To understand the assembly of these complex communities, the Lieberman Lab reconstructs the recent on-person evolution of strains on […]

Resumen de la plática Genomic studies are transforming precision medicine, yet their benefits often overlook diverse, underserved populations. Our research shows that embracing ancestral diversity not only addresses this ethical concern but also enhances genomic discovery, resolution, interpretation, and contextualization. Analyzing lung diseases across multiple biobanks, we found consistent genetic effects and improved our understanding […]

Resumen de la plática Proteins are the machines of life. These diverse macromolecules are essential for all cellular processes. Nature has generated an impressive set of proteins through evolution. Many of its structures and even more sequences are known by now. This enormous amount of data can be leveraged for protein design. The design of […]